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Check prices for these dates

Tonight
12 Jan - 13 Jan
Tomorrow
13 Jan - 14 Jan
This weekend
16 Jan - 18 Jan
Next weekend
23 Jan - 25 Jan

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Our top choices for O Brien hotels

Breakfast area
Hampton Inn & Suites Alachua I-75

Hampton Inn & Suites Alachua I-75

Hampton Inn & Suites Alachua I-75
2.5 star property
Alachua
9.4 out of 10, Exceptional, (479 reviews)
"Good overnight experience on a car trip. Nice staff."
United States
Luis
The price is AU$175
includes taxes & fees
1 Feb - 2 Feb
Hampton Inn & Suites Alachua I-75
Exterior
Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy
2.0 star property
High Springs
10.0 out of 10, Exceptional, (164 reviews)
"Fantastic place! Very nice amenities and service was wonderful"
United States
Annette
The price is AU$294
includes taxes & fees
14 Jan - 15 Jan
Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy
Exterior
Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
3.5 star property
Alachua
9.4 out of 10, Exceptional, (1,009 reviews)
"Great stay. Good breakfast. "
United States
Bob
The price is AU$196
includes taxes & fees
26 Jan - 27 Jan
Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
Lobby
Quality Inn White Springs Suwanee

Quality Inn White Springs Suwanee

Quality Inn White Springs Suwanee
2.5 star property
Live Oak
7.2 out of 10, Good, (626 reviews)
"Clean rooms, very friendly staff"
United States
Kristin L
The price is AU$101
includes taxes & fees
26 Jan - 27 Jan
Quality Inn White Springs Suwanee
Exterior
La Quinta Inn & Suite by Wyndham Lake City

La Quinta Inn & Suite by Wyndham Lake City

La Quinta Inn & Suite by Wyndham Lake City
2.5 star property
Lake City
8.8 out of 10, Excellent, (1,037 reviews)
"Room was clean and all the staff were very nice."
United States
Wayne
The price is AU$159
includes taxes & fees
18 Jan - 19 Jan
La Quinta Inn & Suite by Wyndham Lake City
Down duvets, pillow-top beds, blackout curtains, iron/ironing board
Super 8 by Wyndham Lake City

Super 8 by Wyndham Lake City

Super 8 by Wyndham Lake City
2.0 star property
Lake City
7.2 out of 10, Good, (673 reviews)
"Clean room, friendly staff, fantastic food!"
United States
John
The price is AU$112
includes taxes & fees
15 Jan - 16 Jan
Super 8 by Wyndham Lake City
Suite, 1 King Bed with Sofa bed
Courtyard By Marriott Lake City

Courtyard By Marriott Lake City

Courtyard By Marriott Lake City
3.0 star property
Lake City
9.6 out of 10, Exceptional, (187 reviews)
"The best part of this stay was a room with 2 king beds!!!!! Property was in excellent condition and front desk person was super. Highly recommend."
United States
Joyce
The price is AU$179
includes taxes & fees
25 Jan - 26 Jan
Courtyard By Marriott Lake City
Free daily on-the-go breakfast
Tru by Hilton Lake City

Tru by Hilton Lake City

Tru by Hilton Lake City
2.5 star property
Lake City
9.2 out of 10, Wonderful, (1,007 reviews)
"Very clean and nice staff "
United States
renae
The price is AU$168
includes taxes & fees
25 Jan - 26 Jan
Tru by Hilton Lake City
Suite, Multiple Beds, Accessible, Non Smoking
Comfort Suites Lake City

Comfort Suites Lake City

Comfort Suites Lake City
2.5 star property
Lake City
9.6 out of 10, Exceptional, (1,000 reviews)
"Clean room, great breakfast and staff super friendly "
United States
Gary
The price is AU$180
includes taxes & fees
18 Jan - 19 Jan
Comfort Suites Lake City
Lobby
Fairfield Inn & Suites Lake City

Fairfield Inn & Suites Lake City

Fairfield Inn & Suites Lake City
2.5 star property
Lake City
9.0 out of 10, Wonderful, (179 reviews)
"Very clean, friendly staff, safe and quiet "
United States
Amy
The price is AU$164
includes taxes & fees
25 Jan - 26 Jan
Fairfield Inn & Suites Lake City
BBQ/picnic Area
Americas Best Value Inn Lake City

Americas Best Value Inn Lake City

Americas Best Value Inn Lake City
2.0 star property
Lake City
8.8 out of 10, Excellent, (1,005 reviews)
"Nice quiet and comfortable hotel a little gem."
Canada
Tim
The price is AU$113
includes taxes & fees
25 Jan - 26 Jan
Americas Best Value Inn Lake City
Outdoor pool, open 9:00 AM to 10:00 PM, pool loungers
Hampton Inn & Suites Lake City

Hampton Inn & Suites Lake City

Hampton Inn & Suites Lake City
2.5 star property
Lake City
9.4 out of 10, Exceptional, (1,006 reviews)
"Excellent staff and clean organized room"
United States
Robert
The price is AU$192
includes taxes & fees
18 Jan - 19 Jan
Hampton Inn & Suites Lake City
Pillow-top beds, in-room safe, desk, blackout curtains
Days Inn by Wyndham Lake City I-75

Days Inn by Wyndham Lake City I-75

Days Inn by Wyndham Lake City I-75
2.0 star property
Lake City
7.6 out of 10, Good, (1,002 reviews)
"Staff was great"
United States
Thomas
The price is AU$113
includes taxes & fees
18 Jan - 19 Jan
Days Inn by Wyndham Lake City I-75
Lobby
Best Western Plus Lake City

Best Western Plus Lake City

Best Western Plus Lake City
2.5 star property
Lake City
9.0 out of 10, Wonderful, (1,047 reviews)
"Great place to stay"
United States
Jack
The price is AU$160
includes taxes & fees
18 Jan - 19 Jan
Best Western Plus Lake City
Lobby
Regal Inn

Regal Inn

Regal Inn
2.5 star property
Lake City
8.6 out of 10, Excellent, (548 reviews)
"Comfortable bed, roomy bathroom. Negative:barn door separating bedroom & bathroom (affects privacy), no clothes hangers. "
United States
Linda
The price is AU$104
includes taxes & fees
14 Jan - 15 Jan
Regal Inn
Premium bedding, desk, blackout curtains, soundproofing
Palms Garden Inn

Palms Garden Inn

Palms Garden Inn
2.0 star property
Lake City
7.4 out of 10, Good, (583 reviews)
"Clean and nice staff "
United States
apollo
The price is AU$109
includes taxes & fees
26 Jan - 27 Jan
Palms Garden Inn
Reception
The Blanche

The Blanche

The Blanche
2.0 star property
Lake City
9.2 out of 10, Wonderful, (166 reviews)
"Easy to access building and room with code provided; amazing bed and very clean."
United States
Ruth
The Blanche
Fountain
BlueGem Motel

BlueGem Motel

BlueGem Motel
2.0 star property
High Springs
9.2 out of 10, Wonderful, (400 reviews)
"Beautiful room, very clean and the bed was incredibly soft and comfortable to sleep in! "
United States
Julians
The price is AU$140
includes taxes & fees
26 Jan - 27 Jan
BlueGem Motel
Exterior
Holiday Inn & Suites Lake City by IHG

Holiday Inn & Suites Lake City by IHG

Holiday Inn & Suites Lake City by IHG
3.0 star property
Lake City
8.6 out of 10, Excellent, (1,003 reviews)
"Great place"
United States
John
The price is AU$146
includes taxes & fees
25 Jan - 26 Jan
Holiday Inn & Suites Lake City by IHG
Pillow-top beds, desk, iron/ironing board, free WiFi
Quality Inn Lake City

Quality Inn Lake City

Quality Inn Lake City
2.5 star property
Lake City
8.0 out of 10, Very good, (960 reviews)
"Room clean and nice. Quiet location with many choices for food"
United States
Dennis
The price is AU$120
includes taxes & fees
10 Feb - 11 Feb
Quality Inn Lake City
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Learn more about O Brien

Escape to this rural Florida gem where the Suwannee River offers peaceful kayaking trips and fishing adventures. Nearby Spirit of the Suwannee Music Park hosts live concerts, while O'Brien's local farms welcome visitors for fresh produce and family-friendly activities.

See all hotels in O Brien
kayakers at Rock Bluff Spring on the Suwanneee River, Gilchrist County, Florida

Top O Brien Hotel Reviews

Recent Reviews in O Brien

Americas Best Value Inn Lake City

Americas Best Value Inn Lake City

10/10 Excellent
"Nice quiet and comfortable hotel a little gem."
Tim 1-night trip
Posted 4 days ago
Americas Best Value Inn Lake City

More cheap accommodation in O Brien

Motel 6 – Lake City, Fl – Medical Center

Motel 6 – Lake City, Fl – Medical Center

3340 W US Highway 90 Lake City FL
The price is AU$117 per night from 15 Jan to 16 Jan
AU$117
15 Jan - 16 Jan
includes taxes & fees
8.2/10 Very Good! (90 reviews)

Frequently asked questions

Where is the best place to stay in O Brien?
La Quinta Inn & Suite by Wyndham Lake City, located 18.2 mi (29.3 km) from the heart of O Brien, is a top choice for your stay, based on our traveller data. Two other options for your trip to the area are Tru by Hilton Lake City and Holiday Inn Express & Suites Alachua - Gainesville Area by IHG. See all available top hotels, or vacation rentals in O Brien.
What are some of the best holiday rentals that O Brien has to offer?
Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks!: This highly rated holiday home rental in O Brien is located on the beach, and has a balcony, a garden and a BBQ to put you at ease in your new surroundings. It has 3 bedrooms, as well as a kitchen with a dishwasher, a fridge and a stovetop, so that you can cook with friends or family. You and your friends and family can relax into your holiday with amenities such as a selection of games. Our travellers also rate MARGARITAVILLE BY THE SUWANNEE RIVER & ROYAL SPRINGS PET FRIENDLY as a favourite home for rent in O Brien. See all vacation rentals in O Brien.
If I need to cancel my hotel reservation in O Brien, will I receive a refund?
Yes! You'll find that most hotel bookings are refundable if you cancel before the hotel's cancellation deadline, which is usually within 24-48 hours of the scheduled arrival. If your reservation is non-refundable, you might be able to still cancel and receive a refund within 24 hours of booking. Filter your search by fully refundable to find flexible hotel deals in O Brien.
What are some accommodation options with pools in O Brien?
La Quinta Inn & Suite by Wyndham Lake City: Provides on-the-go, an indoor pool and free self parking. Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks! and Tru by Hilton Lake City are two additional hotels that feature an on-site pool. View all hotels with pools in O Brien.
How is it to stay in O Brien?
Visitors to O Brien will definitely find plenty to explore and enjoy. In O Brien, there are 11 hotels and other accommodation options to choose from. Find out more about O Brien.
What are the top places to visit in O Brien?
Natural beauty is on display at Suwannee River, Ichetucknee River and Ichetucknee Springs State Park. You'll also find Wes Skiles Peacock Springs State Park and Lafayette Blue Springs State Park in the area. Take a look at what more there is to see and do in Expedia's O Brien guide.
What's the seasonal weather in O Brien?
The hottest months are usually July and August, with an average temperature of 27°C, while the coldest months are January and February, with an average of 14°C. Average annual precipitation for O Brien is 1278 mm.

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