Search O Brien hotels

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
16 Nov - 17 Nov
Tomorrow
17 Nov - 18 Nov
Next weekend
21 Nov - 23 Nov
In two weeks
28 Nov - 30 Nov

Filter by

Guest rating
Guest rating
Star rating

Top hotels and accommodation in O Brien

Exterior
Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

3.5 star property
Alachua
9.4 out of 10, Exceptional, (1005)
"Great clean place to stay. "
United States
Mary
The price is AU$198
includes taxes & fees
19 Nov - 20 Nov
Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
Exterior
La Quinta Inn & Suite by Wyndham Lake City

La Quinta Inn & Suite by Wyndham Lake City

2.5 star property
Lake City
8.8 out of 10, Excellent, (1006)
"Excellent hotel. Spacious rooms, comfortable bed, great breakfast and friendly staff. Directly off I-75 for easy on and off. "
United States
Lisa
The price is AU$161
includes taxes & fees
1 Dec - 2 Dec
La Quinta Inn & Suite by Wyndham Lake City
Desk, blackout curtains, iron/ironing board, rollaway beds
Americas Best Value Inn Alachua

Americas Best Value Inn Alachua

2.0 star property
Alachua
4.8 out of 10, (595)
"Staff was helpful and so courteous.."
United States
Christian
The price is AU$96
includes taxes & fees
17 Nov - 18 Nov
Americas Best Value Inn Alachua
Breakfast area
Hampton Inn & Suites Alachua I-75

Hampton Inn & Suites Alachua I-75

2.5 star property
Alachua
9.4 out of 10, Exceptional, (465)
"We would definitely stay here again if we are ever in this area. "
United States
KAREN
The price is AU$175
includes taxes & fees
14 Dec - 15 Dec
Hampton Inn & Suites Alachua I-75
Lobby
Best Western Plus Lake City

Best Western Plus Lake City

2.5 star property
Lake City
9.2 out of 10, Wonderful, (1002)
"Clean room, friendly staff "
United States
Bill
The price is AU$139
includes taxes & fees
1 Dec - 2 Dec
Best Western Plus Lake City
Property amenity
Courtyard By Marriott Lake City

Courtyard By Marriott Lake City

3.0 star property
Lake City
9.6 out of 10, Exceptional, (168)
"Nice place for a weekend trip to the springs close by.Would definitely stay here again."
United States
Mary
The price is AU$184
includes taxes & fees
30 Nov - 1 Dec
Courtyard By Marriott Lake City
Double Room, Non Smoking
High Springs Country Inn

High Springs Country Inn

2.0 star property
High Springs
8.6 out of 10, Excellent, (13)
"The room looked exactly as shown in the image, it was very clean. The everyone I interacted with on the staff was wonderful! If staying in High Springs Florida, diving the Springs or for any other reason, I highly recommend this Inn. "
United States
Randall
The price is AU$124
includes taxes & fees
18 Nov - 19 Nov
High Springs Country Inn
Lobby
Comfort Suites Lake City

Comfort Suites Lake City

2.5 star property
Lake City
9.6 out of 10, Exceptional, (1001)
"Nice clean rooms "
United States
Bethany
The price is AU$177
includes taxes & fees
19 Nov - 20 Nov
Comfort Suites Lake City
Standard Cabin, 1 Queen Bed, Non Smoking | Exterior
Postcard Cabins Gilchrest Spring, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Gilchrest Spring, Outdoor Collection by Marriott Bonvoy

2.0 star property
High Springs
9.8 out of 10, Exceptional, (137)
"Amazing getaway ,, I love the amenities and the firewood and everything was amazing great service perfect escape from reality."
United States
Emperesse
The price is AU$251
includes taxes & fees
18 Nov - 19 Nov
Postcard Cabins Gilchrest Spring, Outdoor Collection by Marriott Bonvoy
Exterior
Tru by Hilton Lake City

Tru by Hilton Lake City

2.5 star property
Lake City
9.2 out of 10, Wonderful, (1002)
"Good hotel"
United States
Frank
The price is AU$188
includes taxes & fees
17 Nov - 18 Nov
Tru by Hilton Lake City
Standard Room, 2 Queen Beds, Non Smoking
Quality Inn White Springs Suwanee

Quality Inn White Springs Suwanee

2.5 star property
Live Oak
7.2 out of 10, Good, (604)
"The room was ok (not good, not bad, just ok). The breakfast was also ok. The room was a bit small for three people."
Canada
Sichao
The price is AU$114
includes taxes & fees
30 Nov - 1 Dec
Quality Inn White Springs Suwanee
Outdoor pool
Baymont by Wyndham Lake City I-75

Baymont by Wyndham Lake City I-75

2.5 star property
Lake City
5.0 out of 10, (1005)
"Friendly staff checked me in. Clean room "
United States
Jeffrey
The price is AU$99
includes taxes & fees
1 Dec - 2 Dec
Baymont by Wyndham Lake City I-75
Individually decorated, desk, laptop workspace, iron/ironing board
Days Inn by Wyndham Lake City I-10

Days Inn by Wyndham Lake City I-10

2.0 star property
Lake City
6.8 out of 10, (1000)
"Was quite and clean, a little dated but it was a good place to sleep they are pet friendly "
United States
William
The price is AU$100
includes taxes & fees
17 Nov - 18 Nov
Days Inn by Wyndham Lake City I-10
Lobby
Fairfield Inn & Suites Lake City

Fairfield Inn & Suites Lake City

2.5 star property
Lake City
9.0 out of 10, Wonderful, (152)
"Clean property and nice staff"
United States
Thomas
The price is AU$169
includes taxes & fees
23 Nov - 24 Nov
Fairfield Inn & Suites Lake City
Outdoor pool, pool loungers
Quality Inn Lake City

Quality Inn Lake City

2.5 star property
Lake City
7.8 out of 10, Good, (944)
"Everything was great about this property and the staff were very friendly and accommodating. "
United States
Andrew
The price is AU$116
includes taxes & fees
16 Dec - 17 Dec
Quality Inn Lake City
Reception
BlueGem Motel

BlueGem Motel

2.0 star property
High Springs
9.2 out of 10, Wonderful, (382)
"Great hotel"
United States
Wesley
The price is AU$173
includes taxes & fees
17 Nov - 18 Nov
BlueGem Motel
BBQ/picnic Area
Americas Best Value Inn Lake City

Americas Best Value Inn Lake City

2.0 star property
Lake City
8.8 out of 10, Excellent, (1002)
"Great value, super polite staff, and clean, comfortable rooms"
United States
chelsea
The price is AU$112
includes taxes & fees
17 Nov - 18 Nov
Americas Best Value Inn Lake City
Lobby
Motel 6 – Lake City, Fl – Medical Center

Motel 6 – Lake City, Fl – Medical Center

2.0 star property
Lake City
8.4 out of 10, Very good, (41)
"Great little motel with extremely nice staff. "
United States
Georgiy
The price is AU$90
includes taxes & fees
30 Nov - 1 Dec
Motel 6 – Lake City, Fl – Medical Center
Lobby
Hampton Inn & Suites Lake City

Hampton Inn & Suites Lake City

2.5 star property
Lake City
9.4 out of 10, Exceptional, (1000)
"It was a great stay "
United States
Miranda
The price is AU$168
includes taxes & fees
30 Nov - 1 Dec
Hampton Inn & Suites Lake City
Pillow-top beds, in-room safe, desk, blackout curtains
Days Inn by Wyndham Lake City I-75

Days Inn by Wyndham Lake City I-75

2.0 star property
Lake City
7.4 out of 10, Good, (1000)
"Very clean! Very friendly staff! "
United States
Marleis
The price is AU$118
includes taxes & fees
8 Dec - 9 Dec
Days Inn by Wyndham Lake City I-75
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Learn more about O Brien

Escape to this rural Florida gem where the Suwannee River offers peaceful kayaking trips and fishing adventures. Nearby Spirit of the Suwannee Music Park hosts live concerts, while O'Brien's local farms welcome visitors for fresh produce and family-friendly activities.

See all hotels in O Brien
kayakers at Rock Bluff Spring on the Suwanneee River, Gilchrist County, Florida

Top O Brien Hotel Reviews

La Quinta Inn & Suite by Wyndham Lake City

La Quinta Inn & Suite by Wyndham Lake City

10/10 Excellent
"Excellent hotel. Spacious rooms, comfortable bed, great breakfast and friendly staff. Directly off I-75 for easy on and off. "
Lisa 1-night trip
Posted 2 days ago
La Quinta Inn & Suite by Wyndham Lake City

More cheap accommodation in O Brien

Best Western Plus Lake City

Best Western Plus Lake City

350 SW Florida Gateway Dr, Lake City, FL
The price is AU$139 per night from 1 Dec to 2 Dec
AU$139
1 Dec - 2 Dec
includes taxes & fees
9/10 Wonderful! (1,001 reviews)

Frequently asked questions

Where is the best place to stay in O Brien?
Best Western Plus Lake City, located 17.9 mi (28.8 km) from the heart of O Brien, is a top choice for your stay, based on our traveller data. Two other options for your trip to the area are La Quinta Inn & Suite by Wyndham Lake City and Holiday Inn Express & Suites Alachua - Gainesville Area by IHG. See all available top hotels, or vacation rentals in O Brien.
What are some of the best holiday rentals that O Brien has to offer?
Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks!: This highly rated holiday home rental in O Brien is located on the beach, and has a balcony, a garden and a BBQ to put you at ease in your new surroundings. It has 3 bedrooms, as well as a kitchen with a dishwasher, a fridge and a stovetop, so that you can cook with friends or family. You and your friends and family can relax into your holiday with amenities such as a selection of games. See all vacation rentals in O Brien.
If I need to cancel my hotel reservation in O Brien, will I receive a refund?
Yes! You'll find that most hotel bookings are refundable if you cancel before the hotel's cancellation deadline, which is usually within 24-48 hours of the scheduled arrival. If your reservation is non-refundable, you might be able to still cancel and receive a refund within 24 hours of booking. Filter your search by fully refundable to find flexible hotel deals in O Brien.
What are some accommodation options with pools in O Brien?
Best Western Plus Lake City: Offers a snack bar/deli, an indoor pool and buffet. Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks! and La Quinta Inn & Suite by Wyndham Lake City are two additional hotels that feature an on-site pool. View all hotels with pools in O Brien.
How is it to stay in O Brien?
Visitors to O Brien will definitely find plenty to explore and enjoy. In O Brien, there are 10 hotels and other accommodation options to choose from. Find out more about O Brien.
What are the top places to visit in O Brien?
Natural beauty is on display at Suwannee River, Ichetucknee River and Ichetucknee Springs State Park. You'll also find Lafayette Blue Springs State Park and Lake City Mall in the area. Take a look at what more there is to see and do in Expedia's O Brien guide.
What's the seasonal weather in O Brien?
The hottest months are usually July and August, with an average temperature of 27°C, while the coldest months are January and February, with an average of 14°C. Average annual precipitation for O Brien is 1278 mm.

Explore a world of travel with Expedia